Breakdown and repair of metabolism in the aging brain
I think the paper should have been titled "How not to publish a large model" The paper publishes a model is large but the way they deploy to the commuity is insane.
To save you hunting for the model, this link is to the GitHub repo
In summary the paper describes a kinetic model of brain metabolism with:
183 processes, which include:
95 enzymatic reactions
19 transport processes (across cell and mitochondrial membranes)
69 other processes (related to ionic currents, blood flow, and other non-enzymatic processes)
Additionally: The model uses 151 differential equations to simulate the dynamics of molecular concentrations.
So its large, but what's really a problem is the model is essentially inaccessible. The entire model is built using one huge Julia program. All the biology has been subsumed into a large set of difficult to read differential equations. There is no sharable SBML model so this won't go to Biomodels and reusing it will be very difficult. Why is this a problem? It means other researchers cannot build on what was undoubtedly, a huge amount of work. I took a screen shot of a small fragment of the Julia program so you can see what you're up against:
